Description: Cambinol (SIRT1/2 Inhibitor IV) is a cell-permeable b-naphthol compound that inhibits the NAD-dependent deacetylase activity of SIRT1/2 (IC50: 56/59 µM, respectively) in a substrate-, but not NAD-, competitive manner. Cambinol inhibits SIRT5 deacetylase activity only at much higher concentrations (IC50...

SIRT1/2 inhibitor IV is a cell-permeable inhibitor of SIRT1 (IC50 = 56 µM) and SIRT2 (IC50 = 59 µM), blocking NAD+-dependent deacetylase activity in a substrate competitive manner. It less effectively inhibits SIRT5 (IC50 >300 µM) and has no effect on class I and II histone deacetylases. By inhibiting SIRT1, SIRT1/2...

Cambinol is an inhibitor of sirtuins, particularly sirtuin1. Cambinol exhibits anti-inflammatory and anticancer chemotherapeutic activities. In various cell lines, cambinol suppresses MAPK and MEK signaling and inhibits expression of pro-inflammatory cytokines such as IL-1 , IL-6, TNF- , and IFN- . Additionally,...