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TAK-243
Item number: TGM-T16974-100mg
Description: TAK-243 (MLN7243) is a selective inhibitor of the ubiquitin-activating enzyme UAE (IC50=1 nM), blocking ubiquitin binding and disrupting both mono-ubiquitin signaling and overall protein ubiquitination. TAK-243 exhibits antitumor activity and promotes apoptosis. Target: Apoptosis, E1/E2/E3 Enzyme,...
| Keywords: | MLN7243 |
| Application: | Ubiquitin-like modifier-activating enzyme 1 (UBA1) inhibitor |
| CAS | 1450833-55-2 |
| MW: | 519.52 D |
From 41.00€
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MLN7243
Item number: Cay30108-1
MLN7243 is an inhibitor of ubiquitin-activating enzyme (UAE, IC50 = 1 nM). It is selective for UAE over NEDD8-activating enzyme (NAE), SUMO-activating enzyme (SAE), and the autophagy-activating enzyme ATG7 (IC50s = 28, 850, and >10,000 nM, respectively). MLN7243 inhibits proliferation in a panel of 30 cancer cell...
| Keywords: | TAK-243, sulfamic acid,... |
| Application: | Ubiquitin-like modifier-activating enzyme 1 (UBA1) inhibitor |
| CAS | 1450833-55-2 |
| MW: | 519.5 D |
From 84.00€
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