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Item number: TGM-TQ0079-10mg

Description: GNE-495 is a potent and specific inhibitor of MAP4K4 with an IC50 of 3.7 nM. Target: MAPK. Smiles: Nc1ncc(C(=O)NC2CN(C2)C(=O)C2CC2)c2ccc(nc12)-c1cccc(F)c1. References: Ndubaku CO et al. Structure-Based Design of GNE-495, a Potent and Selective MAP4K4 Inhibitor with Efficacy in Retinal Angiogenesis. ACS...

Application:	MAP4K4 inhibitor
CAS	1449277-10-4
MW:	405.42 D

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GNE-495

Item number: Cay21808-1

GNE-495 is an orally bioavailable, potent, and selective MAP4K4 inhibitor (IC50 = 3.7 nM). In cell sprouting assays, it increases the number of protrusions. In a mouse model of oxygen-induced retinopathy, GNE-495 normalizes the percentage of pathological vessels and hemorrhagic areas.Formal Name:...

Keywords:	8-amino-N-[1-(cyclopropylcarbonyl)-3-azetidinyl]-2-(3-fluorophenyl)-1,7-naphthyridine-5-carboxamide
Application:	MAP4K4 inhibitor
CAS	1449277-10-4
MW:	405.4 D

From 61.00€ *

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