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K145 hydrochloride
Item number: TGM-TQ0138-5mg
Description: K145 hydrochloride is a selective sphk2 inhibitor with substrate competitiveness and oral activity, with IC50 of 4.3 µM and Ki of 6.4 µM. K145 hydrochloride can induce apoptosis and has strong antitumor activity. Target: S1P Receptor, Apoptosis. Smiles: Cl.CCCCOc1ccc(CC\C=C2/SC(=O)N(CCN)C2=O)cc1....
| Application: | SphK2 inhibitor |
| CAS | 1449240-68-9 |
| MW: | 384.92 D |
From 49.00€
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K145 (hydrochloride)
Item number: Cay11691-1
K145 is a selective inhibitor of sphingosine kinase 2 (SPHK2, Ki = 6.4 µM) with IC50 values of 4.3 and >10 µM for human recombinant SPHK2 and SPHK1, respectively. It inhibits SPHK2, but not SPHK1, activity in U937 cells when used at a concentration of 10 µM. In vivo, K145 (15 mg/kg, i.p.) inhibits tumor growth in a...
| Keywords: | 3-(2-aminoethyl)-5Z-[3-(4-butoxyphenyl)propylidene]-2,4-thiazolidinedione, monohydrochloride |
| Application: | SphK2 inhibitor |
| CAS | 1449240-68-9 |
| MW: | 384.9 D |
From 44.00€
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