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Item number: TGM-T5555-10mg

Description: Siremadlin (NVP-HDM 201) is a potent, orally bioavailable and highly specific p53-MDM2 interaction inhibitor. Target: E1/E2/E3 Enzyme. Smiles: COc1ncc(-c2nc3C(=O)N([C@H](c3n2C(C)C)c2ccc(Cl)cc2)c2cc(Cl)cn(C)c2=O)c(OC)n1. References: Chapeau EA, et al. Resistance mechanisms to TP53-MDM2 inhibition...

Keywords:	NVP-HDM 201
Application:	Targets E3 ubiquitin-protein ligase Mdm2 [EC:2.3.2.27] (MDM2)
CAS	1448867-41-1
MW:	555.41 D

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Siremadlin

Item number: Cay38516-1

Siremadlin is an inhibitor of the protein-protein interaction between the E3 ubiquitin ligase MDM2 and p53 (IC50 = 0.21 nM). It selectively inhibits the MDM2-p53 protein-protein interaction over MDM4-p53, YAP1-TEAD4, PCSK9-LDLR, and Bcl-2-Bak interactions in time-resolved FRET (TR-FRET) assays (IC50s = 3.3, >150,...

Keywords:	HDM201, NVP-HDM201,...
Application:	MDM2-p53 protein-protein interaction inhibitor
CAS	1448867-41-1
MW:	555.4 D

From 40.00€ *

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