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Item number: Cay20055-1

Pixantrone is a DNA topoisomerase II inhibitor. It induces SV40 DNA cleavage in the presence of mouse topoisomerase II and induces DNA single-strand breaks in NCI H187 cells in a concentration-dependent manner. Pixantrone is cytotoxic to L1210 leukemia cells as well as doxorubicin-sensitive and -resistant LoVo colon...

Keywords:	BBR 2778, 6,9-bis[(2-aminoethyl)amino]-benz[g]isoquinoline-5,10-dione, dimaleate
Application:	Topoisomerase II inhibitor
CAS	144675-97-8
MW:	557.5 D

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