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Item number: TGM-T5058-10mg

Description: Pamiparib (BGB-290) is an orally active, potent, highly selective PARP inhibitor with IC50 values of 0.9 nM for PARP1 and 0.5 nM for PARP2. It exhibits strong PARP trapping, has the capability to penetrate the brain, and is used for researching various cancers, including solid tumors. Target: PARP....

Keywords:	BGB-290
Application:	Targets poly [ADP-ribose] polymerase 1 [EC:2.4.2.30] (PARP1)
CAS	1446261-44-4
MW:	298.31 D

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Pamiparib

Item number: Cay33182-10

Pamiparib is an inhibitor of poly(ADP-ribose) polymerase 1 (PARP1) and PARP2 (IC50s = 1.3 and 0.92 nM, respectively). It is selective for PARP1 and PARP2 over PARP3 (IC50 = 0.068 µM) and other PARP isoforms (IC50s = 2.4->100 µM), as well as over tankyrase 1 (TNKS1) and TNKS2 (IC50s = 0.23 and 0.14 µM, respectively)....

Keywords:	BGB-290, (10aR)-2-fluoro-5,8,9,10,10a,11-hexahydro-10a-methyl-5,6,7a,11-tetraazacyclohepta[def]cyclopenta[a]fluoren-4(7H)-one
Application:	Antineoplastic, PARP1 / PARP2 inhibitor
CAS	1446261-44-4
MW:	298.3 D

From 133.00€ *

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