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Item number: Cay37344-100

JAK3-IN-2 is an inhibitor of JAK3 (Ki = 0.07 nM). It is selective for JAK3 over JAK1 and JAK2 (Kis = 320 and 740 nM, respectively). JAK3-IN-2 inhibits IL-2-induced STAT5 gene expression in a reporter assay (IC50 = 70 nM). In vivo, JAK3-IN-2 (100, 300, and 600 mg/kg) reduces paw swelling and ankle bone loss in a rat...

Keywords:	Janus-Associated Kinase 3 Inhibitor 2, JAK3-Inhibitor 2,...
Application:	JAK3 inhibitor
CAS	1443235-95-7
MW:	350.4 D

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