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Item number: TGM-T8482-100mg

Description: Ripretinib (DCC-2618) is an orally bioavailable inhibitor of (KIT) and (PDGFRA). Target: PDGFR, FLT, Apoptosis, VEGFR, c-Kit. Smiles: CCn1c2cc(NC)ncc2cc(-c2cc(NC(=O)Nc3ccccc3)c(F)cc2Br)c1=O. References: Schneeweiss M, et al. The KIT and PDGFRA switch-control inhibitor DCC-2618 blocks growth and...

Keywords:	DCC-2618
Application:	Targets proto-oncogene tyrosine-protein kinase Kit [EC:2.7.10.1] (KIT, SCFR, CD117)
CAS	1442472-39-0
MW:	510.36 D

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Ripretinib

Item number: Cay33782-10

Ripretinib is an inhibitor of KIT and PDGFRalpha (IC50s = 3 and 3.6 nM, respectively). It is selective for KIT and PDGFRalpha over a panel of 300 kinases (IC50s = >100 nM) but does inhibit DDR2, VEGFR2, PDGFRbeta, and Tie2 (IC50s = V654A, KITT670I, KITD816H, KITD816V, and PDGFRalphaD842V (IC50s = 11, 9.2, 18, 25,...

Keywords:	DCC-2618, N-[4-bromo-5-[1-ethyl-1,2-dihydro-7-(methylamino)-2-oxo-1,6-naphthyridin-3-yl]-2-fluorophenyl]-N'-phenyl-urea
Application:	KIT / PDGFRalpha inhibitor
CAS	1442472-39-0
MW:	510.4 D

From 109.00€ *

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