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Item number: TGM-T27089-100mg

Description: CRT-0066854 is a PKCiota and PKCzeta inhibitor. CRT0066854 was able to restore polarized morphogenesis in the dysplastic H-Ras spheroids. Target: Others. Smiles: N[C@H](CNc1nc(nc2sc3CCCCc3c12)-c1ccncc1)Cc1ccccc1. References: Linch M, Sanz-Garcia M, Rosse C, Riou P, Peel N, Madsen CD, Sahai E, Downward...

Keywords:	CRT 0066854, CRT-0066854, CRT0066854 HCl, CRT-0066854 HCl
Application:	PKCiota / PKCzeta inhibitor
CAS	1438881-19-6
MW:	415.55 D

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CRT0066854

Item number: Cay28463-1

CRT0066854 is an inhibitor of PKCiota and PKCzeta (IC50s = 132 and 639 nM, respectively). It also inhibits the Rho-associated kinase II (ROCK2) kinase domain (IC50 = 620 nM). It is selective for these atypical PKCs and ROCK2 over typical PKCs and 98 other kinases in a panel at 1 µM. CRT0066854 decreases...

Keywords:	(2S)-3-phenyl-N1-[5,6,7,8-tetrahydro-2-(4-pyridinyl)[1]benzothieno[2,3-d]pyrimidin-4-yl]-1,2-propanediamine
Application:	PKCiota / PKCzeta inhibitor
CAS	1438881-19-6
MW:	415.6 D

From 67.00€ *

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