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ND-646
Item number: TGM-TQ0243-100mg
Description: ND-646 is an orally bioavailable and allosteric inhibitor of the ACC enzymes ACC1 and ACC2, with IC50 values of 3.5 nM and 4.1 nM for recombinant hACC1 and hACC2, respectively. Target: Acetyl-CoA Carboxylase. Smiles: COc1ccccc1[C@H](Cn1c2sc(c(C)c2c(=O)n(c1=O)C(C)(C)C(N)=O)-c1ncco1)OC1CCOCC1. References:...
| Application: | Acetyl-CoA carboxylase inhibitor |
| CAS | 1434639-57-2 |
| MW: | 568.64 D |
From 77.00€
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ND-646
Item number: Cay34764-1
ND-646 is an inhibitor of acetyl-CoA carboxylase 1 (ACC1) and ACC2 (IC50s = 3.5 and 4.1 nM, respectively, for the human enzymes). It inhibits the production of palmitate and reduces the total fatty acid content in A549 non-small cell lung cancer (NSCLC) cells when used at a concentration of 500 nM. ND-646 (500 nM)...
| Keywords: | 1,4-dihydro-1-[(2R)-2-(2-methoxyphenyl)-2-[(tetrahydro-2H-pyran-4-yl)oxy]ethyl]-alpha,alpha,5-trimethyl-6-(2-oxazolyl)-2,4... |
| Application: | Acetyl-CoA carboxylase inhibitor |
| CAS | 1434639-57-2 |
| MW: | 568.6 D |
From 83.00€
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