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Fenebrutinib
Item number: TGM-TQ0242-10mg
Description: Fenebrutinib (GDC-0853) is a selective and noncovalent inhibitor of Bruton's tyrosine kinase (Btk) with a Ki of 0.91 nM. Target: BTK. Smiles: C[C@H]1CN(CCN1c1ccc(Nc2cc(cn(C)c2=O)-c2ccnc(N3CCn4c5CC(C)(C)Cc5cc4C3=O)c2CO)nc1)C1COC1. References: Erickson RI , et al. Bruton's Tyrosine Kinase Small Molecule...
| Keywords: | GDC-0853 |
| Application: | Targets Bruton agammaglobulinemia tyrosine kinase [EC:2.7.10.2] (BTK) |
| CAS | 1434048-34-6 |
| MW: | 664.8 D |
From 38.00€
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Fenebrutinib
Item number: Cay21346-1
Fenebrutinib is an inhibitor of Bruton's tyrosine kinase (BTK, Kis = 0.91, 1.6, 1.3, 12.6, and 3.4 nM for wild-type BTK, BTKC481S, BTKC481R, BTKT474I, and BTKT474M, respectively). It is selective for BTK over a panel of 287 additional kinases at 1 µM. Fenebrutinib inhibits anti-IgM antibody-induced BTK...
| Keywords: | 2-[1,6-dihydro-3'-(hydroxymethyl)-1-methyl-5-[[5-[(2S)-2-methyl-4-(3-oxetanyl)-1-piperazinyl]-2-pyridinyl]amino]-6-oxo[3,4... |
| Application: | BTK inhibitor |
| CAS | 1434048-34-6 |
| MW: | 664.8 D |
From 35.00€
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