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UNC1999
Item number: TGM-T3057-100mg
Description: UNC1999 is a orally bioavailable, effective and specific inhibitor of EZH2 (IC50=2 nM) and EZH1 (IC50=45). Target: Autophagy, Histone Methyltransferase. Smiles: CCCc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(cc2n(ncc12)C(C)C)-c1ccc(nc1)N1CCN(CC1)C(C)C. References: Konze KD, et al. ACS Chem. Biol. 2013, 8 (6),...
| Application: | Cell-permeable EZH2 inhibitor |
| CAS | 1431612-23-5 |
| MW: | 569.74 D |
From 34.00€
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UNC1999
Item number: Cay14621-1
The histone H3 lysine 27 (H3K27) methyltransferase EZH2 plays an important role in regulating gene expression, and its aberrant activity is linked to the onset and progression of cancer. UNC1999 is a cell-permeable EZH2 inhibitor (IC50 = 2 nM) that is 22-fold selective over EZH1 and >1,000-fold selective over other...
| Keywords: | N-[(1,2-dihydro-6-methyl-2-oxo-4-propyl-3-pyridinyl)methyl]-1-(1-methylethyl)-6-[6-[4-(1-methylethyl)-1-piperazinyl]-3-1H-... |
| Application: | Cell-permeable EZH2 inhibitor |
| CAS | 1431612-23-5 |
| MW: | 569.8 D |
From 44.00€
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