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Item number: Cay40781-10

1A-116 is an inhibitor of Rac1 (IC50 = 4 µM). It reduces the secretion of chemokine (C-X-C motif) ligand 5 (CXCL5), CXCL10, hepatocyte growth factor (HGF), chemokine (C-C motif) ligand 2 (CCL2), and matrix metalloproteinase-2 (MMP-2) from patient-derived acute myeloid leukemia (AML) cells when used at a...

Keywords:	N-(3,5-dimethylphenyl)-N'-[2-(trifluoromethyl)phenyl]-guanidine
Application:	Rac1 inhibitor
CAS	1430208-73-3
MW:	307.3 D

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1A-116

Item number: TGM-T14004-100mg

Description: 1A-116 is a specific Rac1 inhibitor. Target: Rho. Smiles: Cc1cc(C)cc(NC(=N)Nc2ccccc2C(F)(F)F)c1. References: Gonzalez N, et al. Pharmacological inhibition of Rac1-PAK1 axis restores tamoxifen sensitivity in human resistant breast cancer cells. Cell Signal. 2017 Jan,30:154-161.

Application:	Rac1 inhibitor
CAS	1430208-73-3
MW:	307.31 D

From 46.00€ *

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