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Sp-Cyclic AMPS (sodium salt)
Item number: TGM-T21697-1mg
Description: Sp-cAMPS sodium salt is an analog of cAMP that serves as a potent activator of cAMP-dependent PKA I and PKA II, and as a competitive phosphodiesterase (PDE3A) inhibitor with a Ki of 47.6 µM. It also binds the PDE10 GAF domain with an EC50 of 40 µM [1] [2] [3]. Target: Others. Smiles:...
| Application: | cAMP derivate, binds to PDE10 GAF domain |
| CAS | 142439-95-0 |
| MW: | 367.25 D |
From 170.00€
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Sp-Cyclic AMPS (sodium salt)
Item number: Cay14983-1
Several cyclic nucleotide phosphodiesterases (PDE2, -5, -6, -10, and -11) contain a tandem of GAF domains in their N-terminal regulatory region that are thought to mediate cAMP- or cGMP-induced stimulation of adenylyl and guanylyl cyclases. Sp-cyclic AMPS (Sp-cAMPS) is a derivative of cAMP that binds the PDE10 GAF...
| Keywords: | Sp-cAMPS, cyclic 3',5'-[hydrogen (S)-phosphorothioate] adenosine, monosodium salt |
| Application: | cAMP derivate, binds to PDE10 GAF domain |
| CAS | 142439-95-0 |
| MW: | 367.3 D |
From 94.00€
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