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KPT-276
Item number: Cay29158-5
KPT-276 is an orally bioavailable inhibitor of Exportin 1 (XPO1/CRM1) with anticancer activity. In vivo, KPT-276 (150 mg/kg) increases survival and reduces spleen weight and white blood cell count in an MV4-11 acute myeloid leukemia (AML) mouse xenograft model. It also reduces tumor volume and increases survival in...
| Keywords: | (2Z)-3-[3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-1-(3,3-difluoro-1-azetidinyl)-2-propen-1-one |
| Application: | Exportin 1 (XPO1/CRM1) inhibitor, antineoplastic |
| CAS | 1421919-75-6 |
| MW: | 426.3 D |
From 92.00€
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KPT-276
Item number: LKT-K624760.1
CRM1/XPO1 inhibitor.
| Keywords: | KPT276, (Z)-3-(3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-1-(3,3-difluoroazetidin-1-yl)prop-2-en-1-one |
| Application: | CRM1 / XPO1 inhibitor, Nuclear transport inhibitor |
| CAS | 1421919-75-6 |
| MW: | 426.27 D |
From 90.00€
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