Description: CDKI-73 is a potent CDK9 inhibitor (Ki: 4 nM). It shows selective toxicity to CLL cells(LD50=80 nM) versus normal B cell and normal CD34+ cell(LD50>20 uM).The inhibition of CDK9 induces apoptosis and potentiates the effect of cisplatin. Target: Apoptosis, CDK. Smiles:...

CDKI-73 is an inhibitor of Cdk9/cyclin T1, Cdk1/cyclin B, and Cdk2/cyclin A complexes (Kis = 4, 4, and 3 nM, respectively). It is selective for these complexes over the Cdk7/cyclin H complex (Ki = 91 nM). CDKI-73 is cytotoxic to HCT116 colorectal cancer cells (GI50 = In vivo, CDKI-73 (100 mg/kg every three days)...