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Item number: Cay41099-10

CDKI-73 is an inhibitor of Cdk9/cyclin T1, Cdk1/cyclin B, and Cdk2/cyclin A complexes (Kis = 4, 4, and 3 nM, respectively). It is selective for these complexes over the Cdk7/cyclin H complex (Ki = 91 nM). CDKI-73 is cytotoxic to HCT116 colorectal cancer cells (GI50 = In vivo, CDKI-73 (100 mg/kg every three days)...

Keywords:	Asnuciclib, 3-[[5-fluoro-4-[4-methyl-2-(methylamino)-5-thiazolyl]-2-pyrimidinyl]amino]-benzenesulfonamide
Application:	Cdk9-cyclin T1 / Cdk1-cyclin B / Cdk2-cyclin A inhibitor
CAS	1421693-22-2
MW:	394.4 D

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