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GN44028
Item number: TGM-T15396-100mg
Description: GN44028 (N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine) is a hypoxia-inducible factor inhibitor of (HIF)-1 (IC50: 14 nM). GN44028 inhibits hypoxia-induced HIF-1alpha transcriptional activity. However, It can not be suppressing HIF-1alpha mRNA expression, HIF-1alpha protein...
| Keywords: | N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine |
| Application: | HIF-1alpha transcriptional activity inhibitor |
| CAS | 1421448-26-1 |
| MW: | 305.33 D |
From 105.00€
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GN44028
Item number: Cay37289-1
GN44028 is an inhibitor of HIF-1alpha transcriptional activity. It reduces HIF-1alpha reporter gene expression in HeLa cervical cancer cells (IC50 = 14 nM). GN44028 induces cytotoxicity in HCT116 colorectal, HepG2 hepatic, PC3 prostate, and HeLa cancer cells (IC50s = 2.1, 3.7, 25.4, and 2.1 µM, respectively). It...
| Keywords: | N-(2,3-dihydro-1,4-benzodioxin-6-yl)-1,4-dihydro-indeno[1,2-c]pyrazol-3-amine |
| Application: | HIF-1alpha transcriptional activity inhibitor |
| CAS | 1421448-26-1 |
| MW: | 305.3 D |
From 69.00€
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