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EI1
Item number: TGM-T6484-100mg
Description: EI1 (Ezh2 inhibitor) is a potent and selective EZH2 inhibitor with IC50 of 15 nM and 13 nM for EZH2 (WT) and EZH2 (Y641F), respectively. Target: Apoptosis, Histone Methyltransferase. Smiles: CCC(CC)n1ccc2c(cc(cc12)C#N)C(=O)NCc1c(C)cc(C)[nH]c1=O. References: Qi W, et al. Proc Natl Acad Sci U S A. 2012,...
| Keywords: | KB-145943, Ezh2 inhibitor |
| Application: | EZH2 inhibitor |
| CAS | 1418308-27-6 |
| MW: | 390.48 D |
From 38.00€
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EI1
Item number: Cay19146-1
The lysine methyltransferase EZH2 (KMT6), part of polycomb repressive complex 2 (PRC2), catalyzes trimethylation of lysine 27 on histone H3 (H3K27) and is involved in proliferation and aggressive cell growth associated with neoplastic cells. EI1 is an EZH2 inhibitor that has activity against both wild-type and Y641F...
| Keywords: | 6-cyano-N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-1-(1-ethylpropyl)-1H-indole-4-carboxamide |
| Application: | EZH2 inhibitor |
| CAS | 1418308-27-6 |
| MW: | 390.5 D |
From 52.00€
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