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Item number: TGM-T21785-100mg

Description: Tyrphostin AG957, a tyrosine kinase inhibitor with anti-BCR/ABL tyrosine kinase activity restores beta1 integrin-mediated adhesion and inhibitory signaling in chronic myelogenous leukemia hematopoietic progenitors[1]. Target: Bcr-Abl. Smiles: COC(=O)c1ccc(NCc2cc(O)ccc2O)cc1. References: Bhatia R, Munthe...

CAS	140674-76-6
MW:	273.28 D

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AG957

Item number: Cay17259-1

Tyrphostins are tyrosine phosphorylation inhibitors that act by inhibiting tyrosine kinases. AG957 is a tyrphostin that targets transforming Bcr-Abl fusion proteins (p185Bcr-Abl, p210Bcr-Abl), as well as normal c-Abl (IC50s = 4.3, 1, and 7.1 µM, respectively, for human proteins). It also inhibits epidermal growth...

Keywords:	NSC 654705, Tyrphostin AG957, 4-[[(2,5-dihydroxyphenyl)methyl]amino]-benzoic acid, methyl ester
Application:	Tyrosine kinase inhibitor
CAS	140674-76-6
MW:	273.3 D

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