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Item number: TGM-T4428-100mg

Description: CCT241736 is an orally bioavailable dual FLT3/Aurora kinase inhibitor that also inhibits clinically relevant FLT3-resistant mutants including FLT3-ITD and FLT3, CCT241736, an advanced analog of CCT137690, is a preclinical development candidate for the treatment of human malignancies, and in particular...

Application:	FLT3 inhibitor, Aurora kinase inhibitor
CAS	1402709-93-6
MW:	456.37 D

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CCT241736

Item number: Cay26185-10

CCT241736 is a dual inhibitor of Aurora kinases (Kds = 7.5 and 48 nM for Aurora A and B, respectively) and FLT3 (Kds = 6.2, 38, and 14 nM for wild-type, FLT3ITD, and FLT3D835Y, respectively). It also inhibits the activity of 22 additional kinases by greater than 90% in a panel of 386 nonmutant kinases at 1 µM....

Keywords:	6-chloro-7-[4-[(4-chlorophenyl)methyl]-1-piperazinyl]-2-(1,3-dimethyl-1H-pyrazol-4-yl)-3H-imidazo[4,5-b]pyridine
Application:	FLT3 inhibitor, Aurora kinase inhibitor
CAS	1402709-93-6
MW:	456.4 D

From 109.00€ *

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