Description: 4µ8C (IRE1 Inhibitor III)(IC50=76 nM) is an effective and specific IRE1 Rnase inhibitor. Target: IRE1. Smiles: Cc1cc(=O)oc2c(C=O)c(O)ccc12. References: Cross BC, et al. Proc Natl Acad Sci U S A. 2012, 109(15), E869-878.

4µ8C is an inhibitor of inositol requiring enzyme 1 alpha (IRE1alpha), which is a protein located in the endoplasmic reticulum (ER) membrane that has kinase and RNase activities triggered by ER stress. 4µ8C inhibits IRE1alpha splicing of Xbp1 mRNA (IC50 = 6.8 µM) and reduces subsequent gene expression of Erdj4 (IC50...