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BS-181 hydrochloride
Item number: TGM-T6162-100mg
Description: BS-181 hydrochloride (BS-181 HCl) is a highly selective CDK7 inhibitor with IC50 of 21 nM. It is more than 40-fold selective for CDK7 than CDK1, 2, 4, 5, 6, or 9. Target: CDK. Smiles: Cl.CC(C)c1cnn2c(NCc3ccccc3)cc(NCCCCCCN)nc12. References: Ali S, et al. Cancer Res, 2009, 69(15), 6208-6215.
| Keywords: | BS-181 HCl |
| Application: | CDK7 inhibitor |
| CAS | 1397219-81-6 |
| MW: | 416.99 D |
From 31.00€
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BS-181 (hydrochloride)
Item number: Cay17996-10
BS-181 is a Cdk7 inhibitor that blocks the activity of Cdk-activating kinase with an IC50 value of 21 nM. It inhibits Cdk2 at a concentration 35-fold higher than that of Cdk7. BS-181 has been shown to inhibit the phosphorylation of Cdk7 substrates, to promote cell cycle arrest and apoptosis, to inhibit the growth of...
| Keywords: | N5-(6-aminohexyl)-3-(1-methylethyl)-N7-(phenylmethyl)-pyrazolo[1,5-alpha]pyrimidine-5,7-diamine, monohydrochloride |
| Application: | CDK7 inhibitor |
| CAS | 1397219-81-6 |
| MW: | 417 D |
From 61.00€
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