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Item number: TGM-T16484-2mg

Description: PF-05180999 is an inhibitor of phosphodiesterase 2A (IC50: 1.6 nM). Target: PDE. Smiles: Cc1nc(-c2cnn(C)c2-c2ccc(cn2)C(F)(F)F)c2c(ncnn12)N1CCC1. References: Helal CJ, et al. Identification of a Potent, Highly Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor Clinical Candidate. J Med Chem....

Application:	PDE2A inhibitor
CAS	1394033-54-5
MW:	414.39 D

81.00€ *

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PF-05180999

Item number: Cay30374-1

PF-05180999 is a phosphodiesterase 2A (PDE2A) inhibitor (IC50 = 1.6 nM). It is greater than 2000-fold selective for PDE2A over a panel of ten additional PDEs. PF-05180999 increases striatal, cortical, and hippocampal cGMP levels in mice in a dose-dependent manner. In vivo, it inhibits disruption of low frequency...

Keywords:	4-(1-azetidinyl)-7-methyl-5-[1-methyl-5-[5-(trifluoromethyl)-2-pyridinyl]-1H-pyrazol-4-yl]-imidazo[5,1-f][1,2,4]triazine
Application:	PDE2A inhibitor
CAS	1394033-54-5
MW:	414.4 D

From 52.00€ *

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