alpha-Hydroxyglutaric acid (2-HG, Cay-16374) is normally metabolized to 2-oxoglutarate by D- and L-2-hydroxyglutarate dehydrogenases. Mutations in these enzymes cause 2-hydroxyglutaric aciduria, a neurometabolic disorder. Recent studies have found that mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2,...

Description: (2R)-Octyl-alpha-hydroxyglutarate ((2R)-Octyl-2-HG) is a modified form of D-isomer 2-hydroxyglutarate. Target: Pim. Smiles: CCCCCCCCOC(=O)[C@H](O)CCC(O)=O. References: Sulkowski PL, et al. 2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologousrecombination and induces PARP...