Description: Tropifexor (LJN452) is a novel and highly potent agonist of FXR with an EC50 of 0.2 nM. Target: Autophagy, FXR. Smiles: OC(=O)c1cc(F)c2nc(sc2c1)N1[C@H]2CC[C@@H]1C[C@@H](C2)OCc1c(onc1-c1ccccc1OC(F)(F)F)C1CC1. References: Tully DC,etal.Discovery of Tropifexor (LJN452), a Highly Potent Non-bile Acid FXR...

Tropifexor is an agonist of farnesoid X receptors (FXR). It enhances the interaction between the human FXR ligand binding domain and the steroid receptor coactivator 1 (SRC-1) peptide in a homogeneous time-resolved fluorescence (HTRF) coactivator interaction assay (EC50 = 0.2 nM). It increases expression of the FXR...