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Item number: TGM-T6945-100mg

Description: Vps34-PIK-III (VPS34-IN2), a selective inhibitor of VPS34 enzymatic activity, inhibits autophagy and results in the stabilization of autophagy substrates. Target: PI3K, Autophagy. Smiles: Nc1ncc(c(CC2CC2)n1)-c1ccnc(Nc2ccncc2)n1. References: Honda A, et al. Potent, Selective, and Orally Bioavailable...

Keywords:	PIK-III, VPS34-IN2
Application:	VPS34 inhibitor
CAS	1383716-40-2
MW:	319.36 D

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PIK-III

Item number: Cay17002-1

PIK-III is an inhibitor of the type 3 phosphatidylinositol 3-kinase (PI3K) vacuolar protein sorting 34 (Vps34) that binds a unique hydrophobic pocket (IC50 = 18 nM). It is selective for Vps34 over related PI3K isoforms, PI4Kbeta, and mTOR. PIK-III acutely inhibits autophagy and de novo lipidation of LC3, leading to...

Keywords:	Vacuolar Protein Sorting 34 Inhibitor 2, Vps34 Inhibitor 2, Vps34-IN2,...
Application:	VPS34 inhibitor
CAS	1383716-40-2
MW:	319.4 D

From 102.00€ *

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