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Item number: Cay36414-10

LEE011 is a cyclin-dependent kinase 4 (Cdk4) and Cdk6 inhibitor (IC50s = 0.53 and 2.3 nM, respectively). It is selective for Cdk4/6 over Cdk1, Cdk2, Cdk5, Cdk7, and Cdk9 (IC50s = >1,400, >2,500, >2,000, >2,000, and 190 nM, respectively). LEE011 reduces the proliferation of MCF-7 and T47D breast cancer cells (IC50s =...

Keywords:	NVP-LEE011, Ribociclib, butanedioic acid, compd. with...
Application:	Cdk4/6 inhibitor
CAS	1374639-75-4
MW:	552.6 D

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