Description: Vipoglanstat is a prostaglandin E synthase inhibitor and an anti-inflammatory. Vipoglanstat ameliorates leukocyte infiltration and lung injury resulting from both endotoxin-induced and sepsis-induced lung injury. Target: Others. Smiles:...

Vipoglanstat is an inhibitor of microsomal prostaglandin E synthase-1 (mPGES-1, IC50 = =0.5 nM in isolated human whole blood). It reduces LPS-induced increases in the influx of neutrophils and levels of cytokines in bronchoalveolar lavage fluid (BALF), as well as the expression of PTGES, the gene encoding mPGES-1,...