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Item number: TGM-T2043-100mg

Description: Mutant IDH1-IN-1 is a potent inhibitor of the mutant IDH1 R132 h, exhibiting an IC50 of less than 0.1 µM. Target: Dehydrogenase, Isocitrate Dehydrogenase (IDH). Smiles: Cc1ccccc1C(N(C(=O)Cn1cnc2ccccc12)c1cccc(F)c1)C(=O)NC1CCCCC1. References: Janeta Popovici-Muller, et al. Patent WO2012009678 A1.

Keywords:	IDH1-IN-1
Application:	IDH1 R132H inhibitor
CAS	1355326-21-4
MW:	498.59 D

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Mutant IDH1-IN-1

Item number: Cay18394-1

Mutant IDH1-IN-1 is a selective inhibitor of the cancer-associated enzyme mutant isocitrate dehydrogenase 1 (IDH1, Cay-14131) with IC50 values of 42, 4, and 80 nM for homozygous R132H and R132C mutant and heterozygous R132H wild-type enzymes, respectively, for converting alpha-ketoglutarate (alpha-KG) to...

Keywords:	N-[2-(cyclohexylamino)-1-(2-methylphenyl)-2-oxoethyl]-N-(3-fluorophenyl)-1H-benzimidazole-1-acetamide
Application:	IDH1 R132H inhibitor
CAS	1355326-21-4
MW:	498.6 D

From 61.00€ *

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