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Naloxegol oxalate
Item number: TGM-T3355-10mg
Description: Naloxegol oxalate (NKTR-118) is a peripherally-selective opioid antagonist for the treatment of opioid-induced constipation. Target: P450. Smiles: COCCOCCOCC OCCOCCOCCO CCO[C@H]1CC[C@]2([C@H]3Cc4c5[C@]2([C@H]1Oc5c(cc4)O)CCN3CC=C)O.C(=O)(C(=O)O)O. References: Bui K, et al. J Clin Pharmacol. 2016...
| Keywords: | AZ-13337019 oxalate, AZ 13337019, NKTR-118 oxalate, NKTR-118 |
| Application: | Targets mu-type opioid receptor (OPRM1) |
| CAS | 1354744-91-4 |
| MW: | 741.83 D |
From 42.00€
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Naloxegol (oxalate)
Item number: Cay23731-10
Naloxegol is a peripherally acting antagonist of the µ-opioid receptor (Ki = 7.42 nM, pA2 = 7.95). It is selective for the µ-opioid receptor over the delta-opioid receptor (Ki = 866 nM). Naloxegol also acts as a partial agonist of kappa-opioid receptors in vitro (EC50 = 47 nM for [35S]GTPgammaS binding) but lacks...
| Keywords: | AZ 13337019, NKTR-118,... |
| Application: | Opioid receptor antagonist |
| CAS | 1354744-91-4 |
| MW: | 741.8 D |
From 243.00€
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