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Ceralasertib
Item number: TGM-T3338-10mg
Description: Ceralasertib (AZD6738) is an orally active, selective ATR kinase inhibitor with an IC50 of 1 nM. Target: ATM/ATR. Smiles: C[C@@H]1COCCN1c1cc(nc(n1)-c1ccnc2[nH]ccc12)C1(CC1)S(C)(=N)=O. References: Vendetti FP, et al. Oncotarget. 2015. doi: 10.18632/oncotarget.6247.
| Keywords: | AZD6738 |
| Application: | Targets serine/threonine-protein kinase ATR [EC:2.7.11.1] (ATR) |
| CAS | 1352226-88-0 |
| MW: | 412.51 D |
From 43.00€
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AZD 6738
Item number: Cay21035-1
AZD 6738 is an orally bioavailable inhibitor of the serine/threonine protein kinase ataxia telangiectasia mutated (ATM) and Rad3-related (ATR, IC50 = 1 nM). It can inhibit ATR substrate Chk1 Ser345 phosphorylation in cells with an IC50 value of 74 nM. AZD 6738 has been shown to inhibit the proliferation of various...
| Keywords: | 4-[4-[1-[[S(R)]-S-methylsulfonimidoyl]cyclopropyl]-6-[(3R)-3-methyl-4-morpholinyl]-2-pyrimidinyl]-1H-pyrrolo[2,3-b]pyridine |
| Application: | ATM inhibitor, ATR inhibitor |
| CAS | 1352226-88-0 |
| MW: | 412.5 D |
From 67.00€
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