Description: RR6 acts as a selective, reversible, and competitive vanin inhibitor at nanomolar concentration. Target: Others. Smiles: CC(C)(CO)[C@@H](O)C(=O)NCCC(=O)Cc1ccccc1. References: Jansen PA et al. Discovery of small molecule vanin inhibitors: new tools to study metabolism and disease. ACS Chem Biol. 2013 Mar...

RR6 is an inhibitor of the pantetheinase vanin-1 (IC50 = 0.54 µM for the recombinant human enzyme) and is a derivative of the CoA precursor D-pantothenic acid (Cay-17288). It is selective for vanin-1 over biotinidase, cathepsin B, cathepsin L, and papain (IC50s = >200 µM for all). RR6 is active against P. falciparum...