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Item number: TGM-TQ0236-100mg

Description: Tirabrutinib (GS-4059) (ONO-4059) is an orally active Bruton's Tyrosine Kinase (Btk) inhibitor (can cross the blood-brain barrier (BBB)), with an IC50 of 6.8 nM. Tirabrutinib irreversibly and covalently binds to Btk and inhibits aberrant B cell receptor signaling. Tirabrutinib can be used in studies of...

Keywords:	ONO-4059, Velexbru, GS-4059
Application:	Targets Bruton agammaglobulinemia tyrosine kinase [EC:2.7.10.2] (BTK)
CAS	1351636-18-4
MW:	454.48 D

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ONO-4059

Item number: Cay32957-5

ONO-4059 is an inhibitor of Bruton's tyrosine kinase (BTK, IC50 = 2.2 nM). It is selective for BTK over LCK, LYN, and Fyn at 1 µM. ONO-4059 inhibits B cell proliferation and activation in vitro and reduces tumor growth in a TMD8 mouse xenograft model.Formal Name:...

Keywords:	GS-4059, ONO-WG-307, Tirabrutinib,...
Application:	BTK inhibitor
CAS	1351636-18-4
MW:	454.5 D

From 86.00€ *

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