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Item number: TGM-T6S1894-100mg

Description: 1. Linderane was characterized as a mechanism-based inactivator of CYP2C9. Target: P450. Smiles: Cc1coc2C\C(C)=C/CC[C@]34O[C@@H]3[C@@H](OC4=O)c12. References: Determination of linderane in root tuber of Lindera aggregata by HPLC,

Application:	CYP2C9 inhibitor
CAS	13476-25-0
MW:	260.29 D

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Linderane

Item number: Cay27479-10

Linderane is a sesquiterpene that has been found in L. aggregata. It inhibits the cytochrome P450 (CYP) isoform CYP2C9 (Ki = 1.26 µM) in an irreversible and NADPH-dependent manner. Linderane decreases phosphoenolpyruvate carboxykinase (Pck1) and glucose-6-phosphatase (G6pc) gene expression, cAMP concentration, and...

Keywords:	(1aS,4E,10S,10aS)-3,6,10,10a-tetrahydro-5,9-dimethyl-2H-10,1a-(epoxymethano)oxireno[4,5]cyclodeca[1,2-b]furan-12-one
Application:	CYP2C9 inhibitor
CAS	13476-25-0
MW:	260.3 D

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