2 products were found matching "1346242-81-6"!

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Item number: TGM-T3726-100mg

Description: Erdafitinib (JNJ-42756493), a quinoxaline derivative, targets FGFR1/2/3/4. Target: Apoptosis, FGFR. Smiles: COc1cc(OC)cc(c1)N(CCNC(C)C)c1ccc2ncc(nc2c1)-c1cnn(C)c1. References: Verstraete M, et al. In vitro and in vivo evaluation of the radiosensitizing effect of a selective FGFR inhibitor...

Keywords:	JNJ-42756493
Application:	Targets fibroblast growth factor receptor 3 [EC:2.7.10.1] (FGFR3, CD333)
CAS	1346242-81-6
MW:	446.54 D

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JNJ-42756493

Item number: Cay21813-1

JNJ-42756493 is a pan-FGFR inhibitor (IC50s = 1.2, 2.5, 3, and 5.7 nM for FGFR1, -2, -3, and -4, respectively). It is selective for FGFRs over VEGFR2 (IC50 = 36.8 nM). JNJ-42756493 inhibits the proliferation of Ba/F3 cells expressing FGFR1, -3, or -4 (IC50s = 22.1, 13.2, and 25 nM, respectively). It reduces tumor...

Keywords:	Erdafitinib, N1-(3,5-dimethoxyphenyl)-N2-(1-methylethyl)-N1-[3-(1-methyl-1H-pyrazol-4-yl)-6-quinoxalinyl]-1,2-ethanediamine
Application:	FGFR inhibitor
CAS	1346242-81-6
MW:	446.6 D

From 42.00€ *

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