Description: Tolcapone (Ro 40-7592) is a catechol-O-methyltransferase inhibitor employed as an adjunctive therapy with levodopa and carbidopa in the treatment of Parkinson's disease. Target: Apoptosis, Transferase, Beta Amyloid. Smiles: C(=O)(C1=CC(N(=O)=O)=C(O)C(O)=C1)C2=CC=C(C)C=C2. References: Zürcher G, et al....

Tolcapone is a reversible inhibitor of catechol-O-methyltransferase (COMT, Ki = 0.27 nM for human recombinant COMT), an enzyme that degrades catecholamines, including dopamine and L-DOPA (Cay-13248). Tolcapone crosses the blood brain barrier and can inhibit both peripheral and central COMT activity. By inhibiting...