Description: MG-115 (Z-LL-Nva-CHO) is a potent and reversible inhibitor of proteasome , with K i s of 21 nM and 35 nM for 20S and 26S proteasome, respectively. MG-115 specifically inhibit the chymotrypsin-like activity of the proteasome, induces p53-dependent apoptosis [1] [2] [3]. Target: Proteasome. Smiles:...

Solid lyophilized powder. Soluble in DMSO. Potent, reversible and cell permeable proteasome inhibitor. Specifically inhibits the chymotrypsin-like activity of the proteasome, Calpain and cathepsin inhibitor, Apoptosis inducer in Rat-1 and PC12 cells via a p53-dependent pathway, Autophagy activator.

(S)-MG115 is a potent and reversible proteasome inhibitor, targeting the chymotryptic site on the 20S particle (Ki = 21 nM). It reduces the degradation of ubiquitin-conjugated proteins in extracts. (S)-MG115 also blocks the degradation of long- and short-lived proteins in intact cells as well as the proteolytic...