The ubiquitin-proteasome pathway plays an integral role in the selective degradation of intracellular proteins. While important for clearing damaged or misfolded proteins, this proteolytic pathway also regulates the availability of key proteins involved in the control of inflammatory processes, cell cycle...

Soluble in DMSO or ethanol. Potent, cell permeable and selective, reversible proteasome inhibitor. Blocks degradation of short-lived proteins and induces a heat shock response. NF-kappaB activation inhibitor through IkappaB degradation. Cell permeable, reversible peptide aldehyde inhibitor. Calpain and cathepsin...

MG-132 is a proteasome inhibitor that exhibits anti-fibrotic and anti-osteoarthritic activities. In renal interstitial fibroblasts, MG-132 inhibits proliferation and induces apoptosis by activating p53, p21, caspase 3, and Bax. MG-132 also inhibits skeletal muscle atrophy in animal models of chronic obstructive...

Description: MG-132 (Z-Leu-Leu-Leu-al) is a cell-permeable, reversible 26S proteasome inhibitor (IC50=100 nM) that functions as an autophagy activator and induces apoptosis. Target: Apoptosis, Proteasome, Autophagy. Smiles: CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1)C=O. References: Han YH,...