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Simurosertib
Item number: TGM-T12642L-100mg
Description: Simurosertib (TAK-931) is a selective and ATP-competitive cell division cycle 7 kinase inhibitor (IC50: <0.3 nM). Target: CDK. Smiles: Cc1n[nH]cc1-c1cc2[nH]c(nc(=O)c2s1)[C@@H]1CC2CCN1CC2. References: K Iwai, et al. A novel CDC7-selective inhibitor TAK-931 with potent antitumor activity. European Journal...
| Keywords: | TAK-931 |
| Application: | Targets cell division control protein 7 [EC:2.7.11.1] (CDC7) |
| CAS | 1330782-76-7 |
| MW: | 341.43 D |
From 67.00€
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Simurosertib
Item number: Cay32519-1
Simurosertib is an inhibitor of cell division cycle 7 (Cdc7) kinase (IC50 = 0.26 nM). It is selective for Cdc7 over cyclin-dependent kinase 2 (Cdk2) and Rho-associated kinase 1 (ROCK1, IC50s = 6,300 and 430 nM, respectively). It inhibits phosphorylation of DNA replication licensing factor MCM2 in HeLa cells (IC50 =...
| Keywords: | TAK-931, 2-(2S)-1-azabicyclo[2.2.2]oct-2-yl-6-(3-methyl-1H-pyrazol-4-yl)-thieno[3,2-d]pyrimidin-4(3H)-one |
| Application: | Cdc7 kinase inhibitor |
| CAS | 1330782-76-7 |
| MW: | 341.4 D |
From 61.00€
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