Description: VTX-27 is a selective inhibitor of protein kinase C theta (PKC theta) (Kis: 0.08 nM and 16 nM for PKC theta and PKC delta). Target: PKC. Smiles: FC1=C(C=2C=3C(NN2)=NC=CC3)N=C(C(Cl)=C1)N4C[C@@]([C@](C(C)C)(C)O)(NCC4)[H]. References: Jimenez JM, et al. Design and optimization of selective protein kinase C...

Soluble in DMSO. VTX-27 is a potent and selective inhibitor of the PKCtheta enzyme, with over 1000-fold against classical isoforms and over 10000-fold against atypical isoforms. Target: PKC theta

VTX-27 is a PKCtheta inhibitor (Ki = 0.08 nM). It is selective for PKCtheta over PKCalpha, -betaI, -betaII, -gamma, -delta, -epsilon, -eta, -µ, and -zeta with Ki values ranging from 1 to >5,000 nM as well as a panel of seven kinases from the Src, spleen tyrosine kinase (Syk), Tec, and MAP kinase families (Kis =...