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ARRY-382
Item number: TGM-T35333-100mg
Description: ARRY-382 is a highly selective oral inhibitor of CSF-1R with an IC50 of 9 nM. Target: CSF-1R. Smiles: N(C(=O)C=1N2C(=NC1)C=C(OCCN3CCN(C)CC3)C=C2)C4=C5C(=NN(CC=6N=C(C)C=CC6)C5=CC=C4)C7CC7. References: David K Edwards V, et al. Oncotarget . 2018 May 15,9(37):24576-24589.
| Application: | CSF1R inhibitor |
| CAS | 1313407-95-2 |
| MW: | 564.68 D |
From 114.00€
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ARRY-382
Item number: Cay38796-1
ARRY-382 is an inhibitor of the colony-stimulating factor 1 receptor (CSF1R, IC50 = 9 nM). It is selective for CSF1R over PDGFR, c-Kit, and FMS-related tyrosine kinase 3 (FLT3, IC50s = >10,000 nM for all). ARRY-382 (10 µM) induces apoptosis in several primary human chronic lymphocytic leukemia (CLL) cell lines. It...
| Keywords: | N-[3-cyclopropyl-1-[(6-methyl-2-pyridinyl)methyl]-1H-indazol-4-yl]-7-[2-(4-methyl-1-piperazinyl)ethoxy]-imidazo[1,2-a]pyri... |
| Application: | CSF1R inhibitor |
| CAS | 1313407-95-2 |
| MW: | 564.7 D |
From 133.00€
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