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Item number: TGM-T16504-10mg

Description: PF-4693627 is an effective and selective microsomal prostaglandin E synthase-1 inhibitor (IC50=3 nM). It is used for the treatment of inflammation caused by osteoarthritis (OA) and rheumatoid arthritis (RA). Target: Prostaglandin Receptor. Smiles:...

Application:	mPGES-1 inhibitor
CAS	1312815-93-2
MW:	502.43 D

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PF-4693627

Item number: Cay22768-1

PF-4693627 is an orally bioavailable inhibitor of microsomal prostaglandin E (PGE) synthase-1 (mPGES-1, IC50 = 3 nM). It is selective for mPGES-1 over PGDS, TXAS, and 5-LO in HWB-1483 cells, which have IC50 values greater than 50 µM, as well as COX-2 in fetal fibroblasts (IC50 = >10 µM). PF-4693627 inhibits...

Keywords:	1-[5-chloro-6-(4-chlorophenyl)-2-benzoxazolyl]-N-[(1S,3S)-3-(hydroxymethyl)cyclohexyl]-4-piperidinecarboxamide
Application:	mPGES-1 inhibitor
CAS	1312815-93-2
MW:	502.4 D

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