Description: NSC624206 is a ubiquitin E1 (UBA1) inhibitor(IC50 of ~9 µM). Target: Others. Smiles: Cl.CCCCCCCCCC NCCSSCc1ccc(Cl)cc1. References: Dana Ungermannova, et al. Identification and Mechanistic Studies of a Novel Ubiquitin E1 Inhibitor. J Biomol Screen . 2012 Apr,17(4):421-34.

NSC 624206 is an inhibitor of ubiquitin-activating enzyme (E1) that specifically blocks ubiquitin-thioester formation (IC50 = 13 µM) but has no effect on ubiquitin adenylation. Through this action, NSC 624206 prevents the ubiquitination and degradation of the tumor suppressor protein p27 in vitro.Formal Name:...