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RO8994
Item number: TGM-T3517-100mg
Description: RO8994 is a highly effective and specific inhibitor of spiroindolinone small-molecule MDM2, with IC50 of 20 nM (MTT proliferation assays) and 5 nM (HTRF binding assays). Target: p53, E1/E2/E3 Enzyme, Mdm2. Smiles:...
| Application: | MDM2-p53 protein-protein interaction inhibitor |
| CAS | 1309684-94-3 |
| MW: | 613.51 D |
From 34.00€
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RO8994
Item number: Cay25674-1
RO8994 is an inhibitor of the protein-protein interaction between MDM2 and the tumor suppressor p53 in a homogeneous time-resolved fluorescence (HTRF) binding assay (IC50 = 5 nM). It inhibits the proliferation of SJSA-1, RKO, and HCT116 cells with an average IC50 value of 20 nM and increases apoptosis in SJSA-1...
| Keywords: | (2'S,3R,4'S,5'R)-N-[4-(aminocarbonyl)-2-methoxyphenyl]-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-1,2-d... |
| Application: | MDM2-p53 protein-protein interaction inhibitor |
| CAS | 1309684-94-3 |
| MW: | 613.5 D |
From 43.00€
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