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Item number: Cay29505-1

AS-2444697 is an inhibitor of interleukin-1 receptor-associated kinase 4 (IRAK4, IC50 = 21 nM). It is greater than 30-fold selective for IRAK4 over a panel of 146 kinases, but is less than 10-fold selective over PDGFRalpha, PDGFRbeta, TrkA, TrkC, CLK1, Itk, and FLT3. AS-2444697 inhibits IL-1beta-induced IL-6...

Keywords:	N-[3-(aminocarbonyl)-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl]-2-(2-methyl-4-pyridinyl)-4-oxazolecarboxamide,...
Application:	IRAK4 inhibitor
CAS	1287665-60-4
MW:	432.9 D

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