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Dotinurad
Item number: Cay41014-5
Dotinurad is a urate transporter 1 (URAT1) antagonist (IC50 = 0.0372 µM). It is selective for URAT1 over ATP-binding cassette subfamily G member 2 (ABCG2), organic anion transporter 1 (OAT1), and OAT3 (IC50s = 4.16, 4.08, and 1.32 µM, respectively). In vivo, dotinurad (30 mg/kg) decreases plasma levels of urate and...
| Keywords: | FYU-981, (3,5-dichloro-4-hydroxyphenyl)(1,1-dioxido-3(2H)-benzothiazolyl)-methanone |
| Application: | URAT1 antagonist |
| CAS | 1285572-51-1 |
| MW: | 358.2 D |
445.00€
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Dotinurad
Item number: TGM-T15160-100mg
Description: Dotinurad ((3,5-dichloro-4-hydroxyphenyl)(1,1-dioxidobenzo[d]thiazol-3(2H)-yl)methanone) is a potent agent of uricosuric (IC50: 3.6 µM for uric acid). Target: OAT. Smiles: C(=O)(N1C=2C(S(=O)(=O)C1)=CC=CC2)C3=CC(Cl)=C(O)C(Cl)=C3. References: Li X, et al. Pharmacological urate-lowering approaches in...
| Keywords: | (3,5-dichloro-4-hydroxyphenyl)(1,1-dioxidobenzo[d]thiazol-3(2H)-yl)methanone |
| Application: | Antihyperuricemic |
| CAS | 1285572-51-1 |
| MW: | 358.2 D |
From 131.00€
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