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Menin-MLL inhibitor MI-2
Item number: TGM-T2649-100mg
Description: Menin-MLL inhibitor MI-2 (MI2) is a potent menin-MLL interaction inhibitor with IC50 of 446 nM. Target: Epigenetic Reader Domain, Histone Methyltransferase, Apoptosis. Smiles: CCCc1cc2c(ncnc2s1)N1CCN(CC1)C1=NCC(C)(C)S1. References: Grembecka J, et al. Nat Chem Biol. 2012, 8(3), 277-284.
| Keywords: | MI 2, MI-2, Menin-MLL inhibitor 2, Menin-MLL Inhibitor, MI2 |
| Application: | Menin-MLL inhibitor |
| CAS | 1271738-62-5 |
| MW: | 375.55 D |
From 37.00€
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MI-2
Item number: Cay29218-5
MI-2 is an inhibitor of the protein-protein interaction between menin and mixed lineage leukemia (MLL) fusion proteins (IC50 = 446 nM). It binds to menin (Kd = 158 nM) and inhibits the menin interaction with the MLL fusion protein MLL-AF9 in HEK293 cells without affecting protein levels of menin or MLL-AF9. MI-2...
| Keywords: | 4-[4-(4,5-dihydro-5,5-dimethyl-2-thiazolyl)-1-piperazinyl]-6-propyl-thieno[2,3-d]pyrimidine |
| Application: | Menin-MLL fusion protein interaction inhibitor |
| CAS | 1271738-62-5 |
| MW: | 375.6 D |
From 133.00€
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