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Olverembatinib
Item number: TGM-T3071-100mg
Description: Olverembatinib (GZD 824) is an orally bioavailable Bcr-Abl inhibitor for Bcr-Abl(WT, IC50: 0.34 nM) and Bcr-Abl(T315I, IC50: 0.68 nM). Target: Bcr-Abl. Smiles: CN1CCN(Cc2ccc(NC(=O)c3ccc(C)c(c3)C#Cc3cnc4[nH]ncc4c3)cc2C(F)(F)F)CC1. References: Ren X, et al. J Med Chem. 2013, 56(3), 879-894.
| Keywords: | GZD 824 |
| Application: | Targets abelson tyrosine-protein kinase 1 [EC:2.7.10.2] (ABL1) |
| CAS | 1257628-77-5 |
| MW: | 532.56 D |
From 31.00€
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GZD-824
Item number: Cay21508-1
GZD-824 is an orally available inhibitor of a broad spectrum of Bcr/Abl tyrosine kinase mutants including T315I (IC50s = 0.34 and 0.68 nM for wild-type Bcr/Abl and Bcr/AblT315I, respectively). It has been shown to suppress the proliferation of Bcr/Abl-positive K562 and Ku812 human chronic myelogenous leukemia cells...
| Keywords: | 4-methyl-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-3-[2-(1H-pyrazolo[3,4-b]pyridin-5-yl)ethynyl]-be... |
| Application: | Bcr/Abl tyrosine kinase mutant inhibitor |
| CAS | 1257628-77-5 |
| MW: | 532.6 D |
From 43.00€
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