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JGB1741
Item number: Cay10641-1
The sirtuins (SIRTs) are a family of NAD+-dependent histone deacetylases involved in gene regulation that is relevant to longevity, cancer, gene regulation, energy homeostasis, and apoptosis. JGB1741 is a small molecule inhibitor of SIRT1 with an IC50 value of 15 µM in a cell-free assay. It shows relatively weak...
| Keywords: | ILS-JGB-1741,... |
| Application: | SIRT1 inhibitor |
| CAS | 1256375-38-8 |
| MW: | 440.6 D |
From 80.00€
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JGB1741
Item number: TGM-T22094-100mg
Description: JGB1741 (ILS-JGB-1741) is a potent and selective inhibitor of SIRT1 with an IC50 of 15 µM. It modulates the Bax/Bcl2 ratio, cytochrome c release, and PARP cleavage, and increases acetylated p53 levels, leading to p53-mediated apoptosis. JGB1741 can be used in breast cancer studies. Target: Sirtuin....
| Keywords: | ILS-JGB-1741 |
| CAS | 1256375-38-8 |
| MW: | 440.56 D |
From 53.00€
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